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Saying an intelligent ‘NO’ is far more difficult than saying ‘YES’ in life. The ability to say ‘NO’ at the right moment is very much necessary to set right pace and direction in life. Therefore, in practical context, ‘NO’ is not always negative, and hence an intelligent ‘NO’ can contribute a lot for a calm and pleasant life.
Practice it and make it a habit. Then the nature will make it sustainable by triggering necessary genetic engineering!